Naturally myostatin blocked

[resike]

Is al een tijdje bekend, maar zeer postbaar

Myostatin is active in muscles used for movement (skeletal muscles) both before and after birth. This protein normally restrains muscle growth, ensuring that muscles do not grow too large. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has a pattern of inheritance known as incomplete autosomal dominance. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) also have increased muscle bulk, but to a lesser degree.
In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother, a former sprinter, has a mutation in one copy of the gene.[11][12][13][14][15][16]
An American boy born in 2005 (Liam Hoekstra) was diagnosed with a clinically similar condition but with a somewhat different cause:[17] his body produces a functional myostatin, but a defect in his myostatin receptor makes his muscles not respond to the myostatin signal.

Bij liam word myostatin niet geblokkeerd maar op een 1 of andere manier reageert zijn lichaam er niet op.
Geleerden hebben geen verklaring.



YouTube - The world's strongest toddler Part 1

YouTube - The world's strongest toddler Part 2

YouTube - The world's strongest toddler Part 3

YouTube - The world's strongest todler Part 4

YouTube - The world's strongest toddler Part 5

[Kevster]

Hoezo mesomorph.

Bizarre shit, 3 jaar oud en gewoon chinups doen op reps.

[resike]

Een ziekte waar je fysiek beter van word hoe bizar

[Iron Mind]

Ik denk dat we hier toekomstige Mr. Olympia hebben.. Zieke shit, ik ben benieuwd wat er uit zijn DNA onderzoek komt. Volgens mij is het geen ziekte, maar een mutatie van enkele genen of niet?

Bedankt voor het delen!

/edit @ kevster nice nieuwe avatar :P

[Mister XXL]

lucky basterd

[crescere]

Super interessant stukje maar om nu te zeggen dat die kerel superveel geluk heeft daar ben ik nu toch ook niet zo zeker van.

Hoewel ik er niet echt het fijne van weet, wij zullen in ieder geval die myostatin voor een zekere reden produceren, redenen hiervoor zouden nutteloos kunnen geworden zijn (mischien zuiniger met voedsel omgaan) maar er zullen er zeker ook andere zijn de toch wel nog belangrijk zijn (abnormale celdeling, kanker op lange termijn, ... ) mischien ergens cru om te zeggen, maar het zou me niet verbazen moesten ze over 10 jaar realiseren dat die jongen bijvoorbeeld die 40 niet zal halen.


eventjes over iets anders; die myostatin inhibitors, al iemand geprobeerd?

[SpuitJunkie]

myostatin is de toekomst jongens, verdiep je goed in dit materiaal binnekort kunnne we monsters van 150 verwachten

[Kevster]

Niet echt bevorderlijk voor de gewrichtjes het schijnt.

[resike]

Je pezen groeien niet mee en dit brengt waarschijnlijk problemen, maar volgens mij is dit bij ass ook zo.

[resike]

Het duitse jongetje met 2 gemuteerde kopies van myostatin gene

Four and a half years ago, a healthy German boy was born with unusually large muscles. His thigh and upper arm muscles popped out noticeably, and doctors, concerned about his health, have followed his growth. Today the boy’s strength remains extraordinary--he can lift seven-pound dumbbells with his arms extended at his sides.
Scientists have now identified the genetic mutation that gives the boy his strength. By analyzing his DNA, they found a mutation in a gene called myostatin, which regulates the growth of muscles. The mutation shuts down the gene and allows the boy’s muscles to grow large, the researchers report in The New England Journal of Medicine.
The findings could potentially lead to therapies for diseases such as muscular dystrophy, in which muscles weaken and deteriorate. Later this year, Wyeth Pharmaceuticals plans to test in clinical trials an experimental drug for muscular dystrophy that inhibits myostatin.
It is the first time that scientists have identified this type of mutation in humans. Similarly large muscles and mutations in the myostatin gene have been found in mice and cattle, and this led the scientists to look in the myostatin gene in the boy.
The boy’s protruding thigh muscles at just seven months of age.
Image courtesy The New England Journal of Medicine. Seven years ago, Se-Jin Lee of Johns Hopkins University School of Medicine in Baltimore found the mutation in mice, and he has been studying the gene ever since. He found mutations in the myostatin gene in Belgian Blue and Piedmontese cattle—both are muscular breeds of cattle known for their high-quality meat.
More recently, Lee and his colleagues at Hopkins showed that “turning off” the myostatin gene in mice with a form of muscular dystrophy improved their strength, and they have been working with scientists at Wyeth Pharmaceuticals to research drugs to treat muscular dystrophy in humans.
Lee teamed up with Markus Schuelke of University Medical Center, Berlin, and researchers at Wyeth for the study on the boy.
The body building world has also shown a keen interest in myostatin. Supplements are available that purport to increase muscle strength by suppressing myostatin, although none has been approved by the U.S. Food and Drug Administration.
“Myostatin blockade will probably work its way into professional and amateur athletics, as well as into the ever-growing business of physical enhancements,” writes Elizabeth McNally of the University of Chicago, Illinois, in an accompanying commentary to the study in The New England Journal of Medicine.
McNally cautions that “the potential for abuse outside the medical arena is substantial” and further studies are needed to address the dangers of manipulating muscle size.
As for the boy, his health is good, but is being monitored by doctors for any changes, especially in his heart.
The genetic mutation runs in the boy’s family, and he inherited two mutant copies of the myostatin gene. His mother, a former professional athlete, carries a mutation in one copy of the gene; his father has not been revealed.
Other family members have also exhibited considerable brawn. The boy’s grandfather, a construction worker, unloaded curbstones by hand and his great-grandfather also was also said be exceptionally strong.

[resike]

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