Dbol & Winny OF Winny only kuur

[Snuff-Sann]

Beste DnnS.
Liv-52 van Himalaya is 100% kwaliteit. Dan ben je zeker dat je iets goeds in handen hebt.
Er zijn vele produkten in de handel die op pure zakkenvullerij berusten. Vele die beweren maar niet leveren. Himalaya heeft het patent op de echte Liv-52. Genoeg op google te vinden waarin het keer op keer wordt bevestigt.

Sillymarin, milk thistle of mariadistel bied zeker wel een nuttige bijdrage aan het herstel van de gezondheid van de lever.
Zelfs de tabs, pillen, caps of poeders die in een reforma-zaak te verkrijgen zijn. Je dient echter alleen hoger te doseren, dus de aanbevolen dagelijkse hoeveelheid die op het etiketje vermeld staat is niet doeltreffend. Het gaat namelijk om de hoeveelheid werkzame stof.
Er zijn genoeg onderzoeken uitgevoerd die aantonen dat sillymarin wel degelijk in staat is voor herstel te zorgen. Je dient het echter niet in een kuur te gebruiken, maar goed, dat heb ik al eerder gemeld.

Kijk ook even naar wat het kost, geen drol.
Dus waarom niet gewoon een klein stukje zekerheid in een nakuur ingebouwd hebben, alle beetjes helpen.

[onderhandelen]

Dit doet mariadistel wel tijdens de kuur omdat het de werking van androgeen-receptoren verlaagt.

ow ? didnt knew that. Heb je daar wat info over klaar liggen ?

[Snuff-Sann]

ow ? didnt knew that. Heb je daar wat info over klaar liggen ?

Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP

Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP

A number of reports have shown that the polyphenolic flavonoid silymarin (SM) is an effective anticancer agent. Agents with novel mechanisms of blocking androgen receptor (AR) function may be useful for prostate cancer prevention and therapy. Previous studies showed that silibinin (SB), the major active component of SM, could inhibit cell proliferation of a human prostate cancer cell line, LNCaP, by arresting the cell cycle at the G1 phase without causing cell death. This study further delineates the potential molecular mechanism by which SM and SB exhibit antiproliferative effects on androgen-responsive prostate cancer cells by inhibiting function of the AR. We observed that SM and SB inhibited androgen-stimulated cell proliferation as well as androgen-stimulated secretion of both prostate-specific antigen (PSA) and human glandular kallikrein (hK2). Additionally, for the first time, we show that an immunophilin, FKBP51, is androgen regulated and that this up-regulation is suppressed by SM and SB. We further demonstrate that transactivation activity of the AR was diminished by SM and SB using gene transfer of PSA promoter and hK2 androgen-responsive element constructs. However, expression and steroid-binding ability of total AR were not affected by SM in western blotting and ligand-binding assays. Intriguingly, we found that nuclear AR levels are significantly reduced by SM and SB in the presence of androgens using western blotting assay and immunocytochemical staining. This study provides a new insight into how SM and SB negatively modulate androgen action in prostate cancer cells.

Voor kanker-onderzoek natuurlijk positief, echter voor een kuurder wat minder.

[JCorte]

kuur 2 max

[Snuff-Sann]

Heb je allemaal helemaal niet nodig, kost wel, doet niks. Die kruidentuintroep en homeopatische bende hoef je niks van te verwachten....bijgeloof werkt daarin voornamelijk, het zg placebo effect.

Dat spul werkt net zo perfect als de gemiddelde tribulus en andere zg middelen die extra hoge test levels geven.

Voila!

[Hepatoprotective effects of silymarin in androgen... [Med Pregl. 2003] - PubMed result

Med Pregl. 2003;56 Suppl 1:79-83.
[Hepatoprotective effects of silymarin in androgenic-anabolic steroid-induced liver damage].

[Article in Serbian]
Radovanović D, Jovanović D, Mihailović D, Ranković G, Stojiljković N, Dimitrov V.

Abstract
INTRODUCTION:

The use and abuse of anabolic-androgenic steroids (AAS) commonly induces liver damage.

MATERIAL AND METHODS:
The study included 40 male Wistar rats, divided into 4 groups of 10 rats each. Animals in the first experimental group (M), were subjected to progressive systematic forced swimming test, 5 days a week, during 8 weeks. Animals in this group were treated with AAS methandienone, 2 mg/kg BW/day, per os, before swimming, 5 d/w for 8 weeks. After swimming, animals were given three times more food than the laboratory animals of the same age and kind. Animals in the second group (M+S), were subjected to progressive forced swimming test, 5 d/w 8 weeks. Animals in this group were treated with methandienone equally as the experimental group M and received the same amount of food. Apart from that, they received silymarin 20 mg/kg BW/day. Animals in the third group (K), represented the control group, which was neither subjected to swimming test, nor treated with methandienone or silymarin. Animals in this group received the same amount of food as animals in groups M and M+S. Animals in the fourth group (C), also represented a control. This group was not exercised nor treated, and animals received a standard amount of food for laboratory animals of this kind and age. Quantitative analysis of obtained hemataxylin-eosin, periodic acid shift and enzymohistochemical preparations was processed using Digital Image Analysis System: Microimage 3.0.

RESULTS:
It was established that processes in the nuclei of animals in groups M and K were significantly more intensive (p<0.001) in relation to groups M+S and C. The investigation of glycogen showed significantly higher density in the cells of groups M and M+S in comparison to groups K and C. Also, there was a significant difference between groups M+S and M. Density of enzyme activity of glutamate dehydrogenase in hepatocytes of animals in the group M+S was significantly higher in relation to the remaining three groups. A statistically significant difference was not found in enzyme activity of succinate dehydrogenase and lactate dehydrogenase.

DISCUSSION:
In cell nuclei of animals in the experimental group M, in the absence of silymarin effect, methandienone causes damages which induce regenerative processes and in this way increase high intensity activity. Silymarin significantly increases the glycogen density in hepatocytes. Increased activities of GDH are attributed to cell vitality.

CONCLUSION:
The present results show hepatoprotective effects of silymarin in androgenic-anabolic steroid induced liver damage.

[Snuff-Sann]

Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP

Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP

A number of reports have shown that the polyphenolic flavonoid silymarin (SM) is an effective anticancer agent. Agents with novel mechanisms of blocking androgen receptor (AR) function may be useful for prostate cancer prevention and therapy. Previous studies showed that silibinin (SB), the major active component of SM, could inhibit cell proliferation of a human prostate cancer cell line, LNCaP, by arresting the cell cycle at the G1 phase without causing cell death. This study further delineates the potential molecular mechanism by which SM and SB exhibit antiproliferative effects on androgen-responsive prostate cancer cells by inhibiting function of the AR. We observed that SM and SB inhibited androgen-stimulated cell proliferation as well as androgen-stimulated secretion of both prostate-specific antigen (PSA) and human glandular kallikrein (hK2). Additionally, for the first time, we show that an immunophilin, FKBP51, is androgen regulated and that this up-regulation is suppressed by SM and SB. We further demonstrate that transactivation activity of the AR was diminished by SM and SB using gene transfer of PSA promoter and hK2 androgen-responsive element constructs. However, expression and steroid-binding ability of total AR were not affected by SM in western blotting and ligand-binding assays. Intriguingly, we found that nuclear AR levels are significantly reduced by SM and SB in the presence of androgens using western blotting assay and immunocytochemical staining. This study provides a new insight into how SM and SB negatively modulate androgen action in prostate cancer cells.

Voor kanker-onderzoek natuurlijk positief, echter voor een kuurder wat minder.

Ik zou op deze voorgaande post van mij nog even willen reageren.
Vanmorgen nam ik mijn dagelijkse Animal Pak weer in en tot mijn grote verbazing lees ik op de achterkant dat een van de ingredienten mariadistel is, en wel 500mg.
Dat is toch wel zeer vreemd als het werkelijk de werking van adrogene receptoren onderdrukt. Geloof dat bijna alle pro bb'ers animal pak gebruiken zowel off-season als in competitie-verband.
Ik ben dus wat verder gaan zoeken en kwam net een post tegen van iemand die het volgende meldde, wat weleens zou kunnen kloppen:

This article may not be relevant at all.

Prostate cells are different from muscle cells. The major effect of testosterone in prostate is through formation of dihydrotestosterone by 5-alpha reductase. In muscle, it works directly and not through conversion to dihydrotestosterone.

Basic science articles are not meant to be directly used in clinical care. They provide facts, and in addition, may help to add a piece to puzzle.

If you read 'discussion' in the full article, there is an explanation. But simply stated, these lines do not change the over all conclusion.

[GeneralIx]

Ik hoopte al dat je er zelf op zou stuiten inderdaad.

[Snuff-Sann]

Ik hoopte al dat je er zelf op zou stuiten inderdaad.

Tsja, ik kom misschien bij menig persoon over als iemand die alles zo goed schijnt te weten maar in het echte leventje is mijn knowledge slechts het topje van de ijsberg. Ook ik ben nog steeds lerende en dien zo nu en dan mijn standpunt aan te passen.
Ik ben namelijk het onderdrukkende effect van sillymarin op de AR meerdere keren op sites tegengekomen en was van mening dat het cycles negatief zou kunnen beinvloeden, dit is dus gelukkig niet het geval tot mijn genoegen.

[GeneralIx]

Het zou het geval kunnen zijn, maar is niet bewezen met voorgaande studie. Het kan dus nog steeds dat het de AR minder goed functioneren onder invloed van silymarin. En ik weet echt wel dat je ook niet alles weet, maar het is vaak onmogelijk om je die kennis bij te brengen. Ik weet ook niet alles, daar niet van, maar soms zou je opknappen als je wat meer tot je door liet komen.

[Snuff-Sann]

Het zou het geval kunnen zijn, maar is niet bewezen met voorgaande studie. Het kan dus nog steeds dat het de AR minder goed functioneren onder invloed van silymarin. En ik weet echt wel dat je ook niet alles weet, maar het is vaak onmogelijk om je die kennis bij te brengen. Ik weet ook niet alles, daar niet van, maar soms zou je opknappen als je wat meer tot je door liet komen.

Ik doe m'n best kerel, echt waar.

[GeneralIx]

Blij dat te horen. Wellicht gaan we het nog ooit met elkaar kunnen vinden.

[marnop]

Voila!

[Hepatoprotective effects of silymarin in androgen... [Med Pregl. 2003] - PubMed result

Med Pregl. 2003;56 Suppl 1:79-83.
[Hepatoprotective effects of silymarin in androgenic-anabolic steroid-induced liver damage].

[Article in Serbian]
Radovanović D, Jovanović D, Mihailović D, Ranković G, Stojiljković N, Dimitrov V.

Abstract
INTRODUCTION:

The use and abuse of anabolic-androgenic steroids (AAS) commonly induces liver damage.

MATERIAL AND METHODS:
The study included 40 male Wistar rats, divided into 4 groups of 10 rats each. Animals in the first experimental group (M), were subjected to progressive systematic forced swimming test, 5 days a week, during 8 weeks. Animals in this group were treated with AAS methandienone, 2 mg/kg BW/day, per os, before swimming, 5 d/w for 8 weeks. After swimming, animals were given three times more food than the laboratory animals of the same age and kind. Animals in the second group (M+S), were subjected to progressive forced swimming test, 5 d/w 8 weeks. Animals in this group were treated with methandienone equally as the experimental group M and received the same amount of food. Apart from that, they received silymarin 20 mg/kg BW/day. Animals in the third group (K), represented the control group, which was neither subjected to swimming test, nor treated with methandienone or silymarin. Animals in this group received the same amount of food as animals in groups M and M+S. Animals in the fourth group (C), also represented a control. This group was not exercised nor treated, and animals received a standard amount of food for laboratory animals of this kind and age. Quantitative analysis of obtained hemataxylin-eosin, periodic acid shift and enzymohistochemical preparations was processed using Digital Image Analysis System: Microimage 3.0.

RESULTS:
It was established that processes in the nuclei of animals in groups M and K were significantly more intensive (p<0.001) in relation to groups M+S and C. The investigation of glycogen showed significantly higher density in the cells of groups M and M+S in comparison to groups K and C. Also, there was a significant difference between groups M+S and M. Density of enzyme activity of glutamate dehydrogenase in hepatocytes of animals in the group M+S was significantly higher in relation to the remaining three groups. A statistically significant difference was not found in enzyme activity of succinate dehydrogenase and lactate dehydrogenase.

DISCUSSION:
In cell nuclei of animals in the experimental group M, in the absence of silymarin effect, methandienone causes damages which induce regenerative processes and in this way increase high intensity activity. Silymarin significantly increases the glycogen density in hepatocytes. Increased activities of GDH are attributed to cell vitality.

CONCLUSION:
The present results show hepatoprotective effects of silymarin in androgenic-anabolic steroid induced liver damage.

Leuk stukje Snuff, maar ik ben geen lab-ratje.......waar zijn de resultaten op mensen die roken en drinken en allerlei troep hebben gegeten en gedronken jarenlang? Maar ook veel andere dingen slikken/spuiten en aangepaste voeding hebben? Ik zou maar niet teveel afgaan op cleane ratjes met schone levertjes en een clean lichaampje.

Het blijft kruidentuinrommel.
Kan wellicht bij sommigen wat doen, maar naturel gaat het net zo goed.
Als ik al wat zou nemen dan zou ik echte livertabs pakken.

[Snuff-Sann]

Leuk stukje Snuff, maar ik ben geen lab-ratje.......waar zijn de resultaten op mensen die roken en drinken en allerlei troep hebben gegeten en gedronken jarenlang? Maar ook veel andere dingen slikken/spuiten en aangepaste voeding hebben? Ik zou maar niet teveel afgaan op cleane ratjes met schone levertjes en een clean lichaampje.

Het blijft kruidentuinrommel.
Kan wellicht bij sommigen wat doen, maar naturel gaat het net zo goed.
Als ik al wat zou nemen dan zou ik echte livertabs pakken.

Hehehe, kerel, je moest eens weten hoeveel onderzoeken er worden uitgevoerd met ratten. Je moest eens weten hoe belangrijk deze onderzoeken voor de mensheid wel niet zijn.

In 1895, Clark University in Worcester, Massachusetts (United States) established a population of domestic white brown rats to study the effects of diet and for other physiological studies. Over the years, rats have been used in many experimental studies, which have added to our understanding of genetics, diseases, the effects of drugs, and other topics that have provided a great benefit for the health and wellbeing of humankind. Laboratory rats have also proved valuable in psychological studies of learning and other mental processes (Barnett, 2002), as well as to understand group behavior and overcrowding (with the work of John B. Calhoun on behavioral sink). A 2007 study found rats to possess metacognition, a mental ability previously only documented in humans and some primates.[5][6]
Domestic rats differ from wild rats in many ways. They are calmer and less likely to bite; they can tolerate greater crowding; they breed earlier and produce more offspring; and their brains, livers, kidneys, adrenal glands, and hearts are smaller (Barnett 2002).
Brown rats are often used as model organisms for scientific research. Since the publication of the Rat Genome Sequence,[7] and other advances such as the creation of a rat SNP chip, and the production of knockout rats, the laboratory rat has become a useful genetic tool, although not as popular as mice. When it comes to conducting tests related to intelligence, learning, and drug abuse, rats are a popular choice due to their high intelligence, ingenuity, aggressiveness, and adaptability. Their psychology, in many ways, seems to be similar to humans. Entirely new breeds or "lines" of brown rats like the Wistar rat have been bred for use in laboratories. Much of the genome of Rattus norvegicus has been sequenced.[8]


Rat - Wikipedia, the free encyclopedia

Dus blijf jij maar gewoon bij jou standpunt, maakt mij niet uit.
Ik weet beter.
En alle beetjes helpen wanneer we over herstel van de lever praten.

[DnnS-043]

Is toch geen tabs only kuurtje geworden.
Het volgende kuurtje gaat hij aanhouden:

week 1 t/m 4 ; Dianabol 30mg/dag
week 1 t/m 8 ; Deca Duroblin 200mg/week
week 1 t/m 10 ; Testosteron Enanthaat 250mg/week
week 12 t/m 15 ; Nolvadex 30mg/dag

[Snuff-Sann]

Is toch geen tabs only kuurtje geworden.
Het volgende kuurtje gaat hij aanhouden:

week 1 t/m 4 ; Dianabol 30mg/dag
week 1 t/m 8 ; Deca Duroblin 200mg/week
week 1 t/m 10 ; Testosteron Enanthaat 250mg/week
week 12 t/m 15 ; Nolvadex 30mg/dag

Vier weekjes tamo op 20mg per dag is genoeg hoor.
Tevens een stack met 3 stoffen voor een eeste kuur is onverstandig.
Jou buddy's of misschien jou eigen lichaam weet helemaal niet hoe er gereageert gaat worden op roids. Als er zich nare bijwerkingen gaan voordoen probeer dan maar eens uit te vissen waar het vandaan komt.
Gewoon testosteron op 500mg/w als 1e kuur.

Mocht je maatje of jij deze kuur gaan starten zou ik HCG gaan toevoegen.
Vooral omdat deca gebruikt wordt, drukt enorm op je axis en je wilt toch wel weer snel herstelt zijn na de kuur lijkt mij.