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  • #91
    Ketotifen fumarate...........

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    • #92
      Heb dat veel gelezen om zo toch 6-8 weken aan de clen te kunnen zitten.

      Hoop dat ik wel een "beetje" deftig ga kunnen slapen met die clen in me lijf

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      • #93
        What Is It?
        Ketotifen is very safe antihistamine used extensively in Europe to treat bronchial asthma and allergies. It is also being studied as a treatment for colitis. When used for asthma, weight gain and an increase in appetite are among the most frequent side effects. Ketotifen also protects the cells in the stomach, small intestine and perhaps the rest of the gut from a number of toxins. A number of case studies suggest that it may be helpful treating skin problems such as acne. Ketotifen also reduces edema (swelling and puffiness caused by water retention) around sores.

        Ketotifen Studies
        German researchers have published data showing that ketotifen lowers tnf-alpha in the test tube. One study used ketotifen in combination with oxymethadone, a steroid like Megace that helps people gain weight, so it is hard to gauge what effect ketotifen had (the study notes a 14% reduction in TNF-alpha levels and weight gains of 11-12 pounds in less than four weeks). A larger placebo controlled study of this combination is underway. The other study used ketotifen by itself in eight patients with elevated TNF-alpha, (but no wasting). Taking ketotifen for 12 weeks, these patients gained an average of six pounds, had increases in their body cell mass and reductions in their TNF-alpha levels.

        Side Effects and Toxicity
        Ketotifen is virtually non-toxic (although it is not advised for patients with epilepsy). People who took twenty times the recommended dose (in suicide attempts) suffered no serious consequences (other than embarrassment). Its primary side effects seem to be temporary drowsiness, dry mouth,(and other mucuos membranes) appetite stimulation and weight gain.

        Dosing and side effects
        No studies have been done to find the most effective dose but the German researchers used 4 mg ED. Dan Duchaine (who discovered ketos use for BB) suggested 10mg ED but in my experience this much is not needed and makes u far too sleepy. I find that 3-4mg ED seems ideal. However, much higher doses have been shown to be quite safe with no adverse affects other than increased drowsiness and appetite – it will make u hungry for solid foods. You can take it divided in the day or all at once.

        Ketotifen and Clen
        Clenbuterol is a beta 2 agonist which has a limited anabolic effect during its first few days of use and afterward is normally used to fight fat. At higher doses, however, it can be catabolic to muscle and it must be cycled on a 2 week on, 2 week of basis or the beta 2 receptors that clen binds to become saturated and down regulate.

        Ketotifen’s magic is that it upregulates the beta-receptors including the beta 2s that clen uses. As long as you are taking ketotifen, it will continue to clean these receptors, never allowing them to downregulate – even while on a heavy clen cycle. That means you can continue to take clen indefinitely without having to cycle off to regenerate the receptors. 2-3mg ED can upregulate even severely shut down receptors within a week.

        It also means that you don’t need as much clen to get the same benefits. It seems u can take about 30-40% less clen and it be equally effective. FONZ posted that it also increases the number of receptor sites on the surface of the cell, allowing more clen to attach and perhaps this is the reason for the increased efficacy. Ketotifen also seems to lessen the sides of clen including the jitters.

        Ketotifen and ECA
        Perhaps an even better use for ketotifen is taking it with the ECA stack. While the thermogenic effect of ephedrine is not as potent as clen because it doesn't have a high receptor affinity, and it is not limited to beta-2 receptors. In fact it seems to have a good effect on beta 3 receptors as well, which act as a type of thermogenic messenger and over half of ephedrine effect is from beta-3 stimulation. Clen has almost no effect on beta 3 however. So by keeping the beta 2 receptors up, ketotifen can allow the benefits of continuous beta 2 and beta 3 stimulation from ephedrine.

        "Ephedrine is believed to have some direct effect on both alpha adrenoceptors and beta adrenoceptors, but AT THERAPEUTIC DOSES, ephedrine exerts its thermogenic effect almost entirely via stimulating noradrenaline release from the sympathetic nerve terminals [endings] . . . at least 40% of the [thermogenic] response is mediated by an atypical receptor, which is presumed to be the beta 3-adrenoceptor."

        from
        Liu YL, Toubro S, Astrup A, Stock MJ Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans Int J Obes Relat Disord. Sep;19(9). 678-685

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        • #94
          Mhhh waar ga ik dat nou weer halen :P lijkt me zeer goed spull!

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          • #95
            Originally posted by Domenique View Post
            Mhhh waar ga ik dat nou weer halen :P lijkt me zeer goed spull!

            United Pharmacies - Search Results

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            • #96
              Artikel waarin de auteur het heeft over het clean houden van receptoren... Maakt de rest van zijn verhaal niet echt geloofwaardiger. Sowieso: iets met de bijwerkingen honger en aankomen, in de mix zetten met een vetverbrander... Hoe krijg je het verzonnen. Daarnaast het idee om clen niet te cyclen... Ja, qua receptor gevoeligheid wellicht geen nadelige effecten (let op het woordje wellicht), maar ik denk dat je hartspier zich er anders onder zal voelen.
              "Een zoektocht naar kennis moet los staan van het moreel van goed of kwaad, anders is die toch gedoemd niet volledig te zijn." - Genjuro

              sigpic

              "Rock is overpowered. Paper is fine" -Scissors-

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              • #97
                Ik weet het kerel, tis wederom een poepverhaal.

                Ik doelde meer op twee weken clen, twee weken eca. Icm ketotifen gewoon heel erg goed te doen, geen kruis-tolerantie.

                Honger en aankomen is wanneer je het only gaat gebruiken.
                Samen met clen en/of ephedrine heb je daar geen last van.

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                • #98
                  Als jij het zegt.
                  "Een zoektocht naar kennis moet los staan van het moreel van goed of kwaad, anders is die toch gedoemd niet volledig te zijn." - Genjuro

                  sigpic

                  "Rock is overpowered. Paper is fine" -Scissors-

                  Comment

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